Pondicherry University has established Memoranda of Understanding (MOUs) and Agreements with a variety of institutions to enhance its operations in research and education across multiple disciplines. These agreements aim to foster the exchange of students, scholars, faculty, and administrative staff, promote collaborative research, and facilitate cultural and academic initiatives, as well as the sharing of knowledge and research resources. The University has formed partnerships with both national and international governmental bodies, organizations, and private, cooperative, academic, and research institutions.

The primary aim of an MOU among universities, institutions, industries, research universities, foundations, and societies is to create a framework for cooperative efforts in academic and research activities involving faculty, research scholars, students from all disciplines, and academic administration. Such agreements are designed to be mutually advantageous, promoting the development of joint studies, research, training activities, and other exchanges of shared interest.

Currently, the University has signed 43 MOUs with international universities and institutions, along with 53 MOUs with national institutions, corporate entities, and private organizations, facilitating the exchange of academic resources, faculty, scholars, students, and collaborative projects.