Dr. V. Thillai Sekar
About
Research Area
Dr. V. Thillai Sekar, Associate Professor in the Department of Microbiology, Pondicherry University, and awarded Ph.D. in Microbiology, University of Madras, Chennai, India in 2007. He was awarded with visiting scientist fellowship from National Science Council, Taiwan and served as Postdoctoral fellow in the University of California, Irvine and Stanford University, USA for 6 years. He also served as Research Scientist in Stanford University and as Senior Research Scientist in the University of Texas Southwestern Medical Center, Dallas, USA for over 8 years. He was member of various scientific societies including World Molecular Imaging Society (WMIS), American Society of Gene and Cell Therapy (ASGCT), and Society for Immunotherapy of Cancer (SITC). He was awarded with Visiting Scientist fellowship award, ICMIC award and various travel grant awards. His current research focus on developing antibody mimetics such as nanobody and affibody, and designing genetically encoded optical imaging sensors to screen bio-drugs from microbes, and other natural sources.
Notable & Recent Publications
Pandurangi R, Thillai Sekar, Paulmurugan R. Restoration of the Lost Human Beta Defensin-1 Protein in Cancer as a Strategy to Improve the Efficacy of Chemotherapy. Journal of Medicinal Chemistry. 2024. 67(16)
Thillai V. Sekar, Eslam Elghonaimy, Katy L. Swancutt, Sebastian Diegeler, Isaac Gonzalez, Cassandra Hamilton, Peter Q. Leung, Jens Meiler, Cristina E. Martina, Michael Whitney, and Todd A. Aguilera. In vivo selection of nanobodies for accessible epitopes on immune cells in the tumor microenvironment. Nature Communication. 2023. 14, 7473.
Malhotra M, Sekar TV, Ananta JS, Devulapally R, Afjei R, Babikir HA, Paulmurugan R, Massoud TF. Targeted nanoparticle delivery of therapeutic antisense microRNAs presensitizes glioblastoma cells to lower effective doses of temozolomide in vitro and in a mouse model. Oncotarget. 2018. 9(30), 21478
Sekar TV, Foygel K, Massoud TF, Gambhir, SS, Paulmurugan R. A transgenic mouse model expressing an ERĪ± folding biosensor reveals the effects of Bisphenol A on estrogen receptor signaling. Scientific Reports. 2016. 6, 34788
Sekar TV, Foygel K, Devulapally R, Kumar V, Malhotra S, Massoud TF, Paulmurugan R. Molecular Imaging Biosensor Monitors p53 Sumoylation in Cells and Living Mice. Analytical Chemistry. 2016. 88(23). 11420-11428
