Dr. T. Jayakumar
About
Research Area
Dr. T. Jayakumar obtained his Ph.D. in Environmental Sciences from the Bharathidasan University, Tiruchirappalli, Tamil Nadu, India. He seems to have a strong academic and research background, particularly in environmental sciences with a focus on oxidative stress and molecular biology. His work on the antioxidant properties of mushroom Pleurotus ostreatus, specifically in relation to hepatotoxicity induced by carbon tetrachloride (CCl4), highlights his proficiency in both theoretical knowledge and practical lab techniques. His recognition for outstanding performance by the UGC review committee underscores the quality and impact of his research.
His postdoctoral work at Taipei Medical University marks a significant expansion in his research expertise, transitioning from environmental sciences to biomedical applications, particularly in the treatment of inflammatory human diseases such as cardiovascular diseases, stroke, arthritis, and cancer. His focus on both natural bioactive compounds and novel organometallic compounds for therapeutic purposes demonstrates his broad scientific interests.
He has participated in international forums, like the stroke conference in the USA. His publications around 135, including 12 major reviews in high-impact journals like JBC and Autophagy with about 5000 citations, an h-index of 30, and an i10-index of 65. He visited prestigious institutions like Harvard Medical School and MIT in Boston, USA.
Notable & Recent Publications
Jayakumar T, Huang HC, Hsia CW, Trang NTT, Fong TH, Khamrang T, Manubolu M, Sheu JR, Hsia CH. Ruthenium derivatives protect LPS-induced liver injury via attenuating inflammatory responses, NF-kB signaling and free radical production: An SAR study. Bioorganic Chemistry, 2020, doi: 10.1016/j.bioorg.2020.103639. IF: 5.275
Lee TY, Lu WJ, Changou CA, Hsiung YC, Trang NTT, Lee CY, Chang TH, Jayakumar T, Hsieh CY, Yang CH, Chang CC, Chen RJ, Sheu JR, Lin KH. Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK-MTOR to sphingolipid metabolism. Autophagy, 2021, 1-18. IF. 16.016
Jayakumar T, Hou SM, Chang CC, Fong TH, Hsia CW, Chen YJ, Huang WC, Saravana Bhavan P, Manubolu M, Sheu JR, Hsia CH. Columbianadin dampens in vitro inflammatory actions and inhibits liver injury via inhibition of NF-κB/MAPKs: impacts on OHo radicals and HO-1 expression. Antioxidant, 2021, 10(4), 553. IF: 6.312
"Jayakumar T, Chun-Ming Yang, Ting-Lin Yen, Chia-Yuan Hsu, Joen-Rong Sheu, Chih-Wei Hsia, Manjunath Manubolu, Wei-Chieh Huang, Cheng-Ying Hsieh and Chih-Hsuan Hsia. Anti-Inflammatory Mechanism of An Alkaloid Rutaecarpine in LTA-Stimulated RAW 264.7 Cells: Pivotal Role on NF-κB and ERK/p38 Signaling Molecules. International Journal of Molecular Sciences, 2022, 23, 5889. IF: 6.02"
"Jayakumar T, Huang CJ, Yen TL, Hsia CW, Sheu JR, Saravana Bhavan P, Wei-Chieh Huang WC, Hsieh CY, Hsia, CH. Activation of Nrf2 by Esculetin Mitigates Inflammatory Responses through Suppression of NF-κB Signaling Cascade in RAW 264.7 Cells, Molecules, 2022, 27, 5143, 1-14."
