Dr. C. Subbulakshmi (UGC – FRP Assistant Professor)
About
Research Area
I received PhD from the University of Göttingen, Germany and pursued postdoctoral fellowships at Bielefeld University, Germany; Harvard Medical School, USA and University of Toronto, Canada. Also, I held JSPS short-term fellowship at Hokkaido University, Japan. Later, I joined Vision Research Foundation, Chennai, as a Senior Scientist and initiated studies on neuronal degeneration in human Retina. Subsequently, I became an assistant professor through UGC-Faculty Recharge Program (UGC-FRP) at Pondicherry University where I have established a research program on ‘Retina in Health and Disease’. The long-term goal is to identify the disease mechanisms and drug targets for human retinal blinding disorders.
The ‘Sensorineural Engineering and Cell Therapeutics lab’ has two arms where one is primarily focusing on Retinal disease biology, especially, the regulatory mechanisms of retinal degenerative diseases to identify drug targets and relevant biomarkers from donor eyes and patient samples. The other arm is, Translational unit which is in the process of creating pre-clinical drug screening models like human retinal explant cultures, in vitro retinal barriers, bio-artificial retina-on-a-chip and retinal organoids for disease modeling and drug development process. My research projects involve a strong interfacing between ophthalmologists, optometrists, patients and scientists from varied fields. The insights gained will provide fundamental knowledge with broad biomedical application.
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Publications
Notable Publications
Sivagurunathan S, Raman R and Subbulakshmi Chidambaram* (2018). PIWI-like protein, HIWI2: A novel player in proliferative diabetic retinopathy. Experimental Eye Research, 177:191-196. DOI:10.1016/j.exer.2018.08.018
Palanisamy K, Nareshkumar RN, Sivagurunathan S, Raman R, Sulochana KNS and Subbulakshmi Chidambaram* (2018). Anti-angiogenic effect of adiponectin in human primary microvascular and macrovascular endothelial cells. Microvascular Research, DOI: 10.1016/j.mvr.2018.08.002.
Sudha D, Kohansal-Nodehi M, Kovuri P, Manda SS, Neriyanuri S, Gopal L, Bhende P, Subbulakshmi Chidambaram*and Arunachalam JP* (2017). Proteomic profiling of human intraschisis cavity fluid. Clinical Proteomics, 14:13.
Subbulakshmi Chidambaram, Nina Müllers, Katrin Wiederhold, Volker Haucke, and Gabriele Fischer von Mollard (2004). Specific interaction between SNAREs and epsin N-terminal homology (ENTH) domains of epsin-related proteins in trans-Golgi network to endosome transport. J Biol Chem. 6; 279(6): 4175-9.
Meik Dilcher, Beate Veith, Subbulakshmi Chidambaram, Enno Hartmann, Hans Dieter Schmitt and Gabriele Fischer von Mollard (2003). Use1p is a yeast SNARE protein required for the traffic from the Golgi to the ER. EMBO J, 22:14, 3664-3674.
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