Dr. B. Sudhakar

Research Area

I obtained a Ph.D. degree from the Indian Institute of Science (IISc), Bangalore where I acquired experience in studying cell cycle regulation. Subsequently, I spent over 10 years in the USA as a full-time researcher at various reputed Universities. In late 2010, I moved to Pondicherry University and established a laboratory which focuses on the epigenetic mechanisms of eukaryotic cell proliferation and differentiation. We investigate i) transcriptional and translational regulation of major epigenetic regulators; DNMT3B, EZH2, CUL4B etc., ii) identification of novel DNMT3B splice variants from various cancer cells and stem cells differentiation, iii) effect of epigenetic regulators on neurodegenerative diseases.

Research Guidance
0 years
Teaching Experience

Notable Publications

"Baluchamy S, Rajabi H, Thimmapaya R, Navaraj A and Thimmapaya,B Repression of c-Myc and inhibition of G1 exit in cells conditionally overexpressing p300 that is not dependent on its histone acetyltransferase activity. Proc. Natl. Acad. Sci. USA, (PNAS). 100 (16): 9524-9529 (2003). "

"Baluchamy S, Sankar N, Navaraj A, Moran E, and Thimmapaya, B. Relationship between E1A binding to cellular proteins c-Myc activation and S phase induction. Oncogene. 1 (5): 781-7 (2007). "

"Mahmud N, Petro B, Baluchamy S, Li X, Taioli S, Lavelle D, Quigley J, Suphangul M, Araki K. Differential effects of epigenetic modifiers on the expansion and maintenance of human cord blood stem/progenitor cells. Biology of Blood and Marrow Transplantation. 20(4):480-489 (2014)."

"Singh P, Sarvagalla S, Elango P, Mohane C and Baluchamy S*. Identification of a novel leukemic specific splice variant of DNMT3B and its stability. Medical Oncology. 34(8):145 (2017). "

"Ashok C, Owais S, Srijyothi L, Selvam M, Ponne S and Baluchamy S*. A feedback regulation of CREB activation through the CUL4A and ERK signaling. Medical Oncology. 36(2): 20 (2019). "

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