Dr. B. Syed Ibrahim
About
Research Area
My research explores the functional interplay between MICOS (Mitochondrial Contact Site and Cristae Organizing System), TLRs (Toll-like Receptors), and HYALs (Hyaluronidases) in cellular homeostasis and signaling. MICOS is essential for maintaining mitochondrial architecture, influencing bioenergetics and apoptosis. TLRs, a key regulator of innate immunity, mediates inflammatory responses, while HYALs, traditionally associated with hyaluronan degradation, has emerging roles in cellular metabolism and signal transduction. Understanding the structure, function and dynamics of these proteins could reveal novel mechanisms like mitochondrial dynamics, immune activation, and extracellular matrix remodeling, with implications for inflammation-related diseases and metabolic disorders.
Notable & Recent Publications
"The pathogenic effect of SNPs on structure and function of human TLR4 using a computational approach. Prakasam P, Abdul Salam AA, Syed Ibrahim, B,. J Biomol Struct Dyn. 2023; 41(21):12387-12400. "
"Computational Investigations of Indanedione and Indanone Derivatives in Drug Discovery: Indanone Derivatives Inhibits Cereblon, an E3 Ubiquitin Ligase Component. Upendra, N., Syed Ibrahim, B., Ummul Halilunnisa, M., Mazhuvancherry, K., Abdul Ajees, A. Comp Bio and Chemistry., Oct 2022, 107776"
"Structural impact of pathogenic SNPs on β-tubulin using molecular dynamics study. Ummul Halilunisha, MH., Syed Ibrahim, B. J Biomol Struct Dyn. 2023; 41(17): 8230-8240."
"Unravelling the distinctive mode of cooperative and independent interaction mechanism of 1-butyl-2,3-dimethylimidazolium tetrafluoroborate ionic liquid with model transport proteins by comprehensive spectroscopic and computational studies. Sharma, A.S., Viswadevarayalu, A., Christian Bharathi, A., Anand, K., Ali, S., Li, H., Syed Ibrahim, B., Quansheng Chen, Journal of Molecular Structure, V1205, 2020, 127591"
"The pathogenicity, structural and functional exploration of human HMGB1 single nucleotide polymorphisms using in silico study. Santhiya, P., Christian Bharathi, A., Syed Ibrahim, B. J Biomol Struct Dyn. (38), 4471-4482, 2019."
