Dr. T. Jayakumar
About
Research Area
Dr. T. Jayakumar obtained his Ph.D. in Environmental Sciences from Bharathidasan University, Tiruchirappalli, Tamil Nadu, India. His doctoral research on the antioxidant and hepatoprotective properties of the edible mushroom Pleurotus ostreatus against carbon tetrachloride (CCl₄)-induced liver toxicity demonstrated expertise in oxidative stress biology, antioxidant mechanisms, and experimental animal models. His research excellence was recognized by the University Grants Commission (UGC) Review Committee.
He completed postdoctoral research at Taipei Medical University, Taiwan, where he expanded his expertise into biomedical sciences, focusing on inflammatory and oxidative stress-related diseases, including cardiovascular diseases, stroke, arthritis, liver disorders, neurodegenerative diseases, and cancer. His research integrates natural bioactive compounds, phytochemicals, nutraceuticals, and novel therapeutic molecules for disease prevention and treatment.
Dr. Jayakumar’s research interests include Environmental Toxicology, Environmental Health, Molecular Toxicology, Oxidative Stress Biology, Bioremediation, Phytoremediation, Environmental Biotechnology, Pharmaceutical and Emerging Contaminant Biodegradation, Environmental Pollution Monitoring, Phytotherapy, Natural Product Drug Discovery, Antioxidant Analysis in Plants and Animals, Functional Foods and Nutraceuticals, Hepatoprotection, and Translational Biomedical Research. His work emphasizes sustainable environmental technologies, pollution control, pharmaceutical biodegradation, environmental risk assessment, and the discovery of plant- and mushroom-derived bioactive compounds for therapeutic applications.
He has participated in several international scientific conferences, including a stroke conference in the United States, and has visited Harvard Medical School and the Massachusetts Institute of Technology (MIT), Boston, USA, for academic collaboration and scientific exchange. Dr. Jayakumar has published approximately 150 peer-reviewed research articles, including 15 review articles in high-impact journals such as Journal of Biological Chemistry (JBC) and Autophagy. His publications have received over 5,000 citations, with an h-index of 37 and an i10-index of 84, reflecting the international impact of his research in environmental and biomedical sciences.
Notable & Recent Publications
Jayakumar T, Huang HC, Hsia CW, Trang NTT, Fong TH, Khamrang T, Manubolu M, Sheu JR, Hsia CH. Ruthenium derivatives protect LPS-induced liver injury via attenuating inflammatory responses, NF-kB signaling and free radical production: An SAR study. Bioorganic Chemistry, 2020, doi: 10.1016/j.bioorg.2020.103639. IF: 5.275
Lee TY, Lu WJ, Changou CA, Hsiung YC, Trang NTT, Lee CY, Chang TH, Jayakumar T, Hsieh CY, Yang CH, Chang CC, Chen RJ, Sheu JR, Lin KH. Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK-MTOR to sphingolipid metabolism. Autophagy, 2021, 1-18. IF. 16.016
Jayakumar T, Hou SM, Chang CC, Fong TH, Hsia CW, Chen YJ, Huang WC, Saravana Bhavan P, Manubolu M, Sheu JR, Hsia CH. Columbianadin dampens in vitro inflammatory actions and inhibits liver injury via inhibition of NF-κB/MAPKs: impacts on OHo radicals and HO-1 expression. Antioxidant, 2021, 10(4), 553. IF: 6.312
"Jayakumar T, Chun-Ming Yang, Ting-Lin Yen, Chia-Yuan Hsu, Joen-Rong Sheu, Chih-Wei Hsia, Manjunath Manubolu, Wei-Chieh Huang, Cheng-Ying Hsieh and Chih-Hsuan Hsia. Anti-Inflammatory Mechanism of An Alkaloid Rutaecarpine in LTA-Stimulated RAW 264.7 Cells: Pivotal Role on NF-κB and ERK/p38 Signaling Molecules. International Journal of Molecular Sciences, 2022, 23, 5889. IF: 6.02"
"Jayakumar T, Huang CJ, Yen TL, Hsia CW, Sheu JR, Saravana Bhavan P, Wei-Chieh Huang WC, Hsieh CY, Hsia, CH. Activation of Nrf2 by Esculetin Mitigates Inflammatory Responses through Suppression of NF-κB Signaling Cascade in RAW 264.7 Cells, Molecules, 2022, 27, 5143, 1-14."
