Dr. Hannah Rachel Vasanthi

Designation: 
Professor
Gender: 
Female
Date Of Joining: 
02/09/2010
Academic
Academics: 
DegreeSpecializationUniversity / InstitutionYear of Completion
1Ph.D.Bio-chemistry (Biochemical Pharmacology)Tamil University2002
2M.Phil.Cardiac Science (Preventive Cardiology)BITS-Pilani1996
3M.Sc.Bio-chemistryUniversity of Madras1994
4B.Sc.Bio-chemistryUniversity of Madras1992
Total Experience: 
15 Years
Area of Specialization/Interest: 
  • Biochemical Pharmacology & Toxicology(Metabolic Disorders)
  • Herbal Drug Development
Publications (in last 3 years): 

Research Articles
2009:

  1. Prasanna Galhena, Ira Thabrew, Mayuri G. Tammitiyagodage and Hannah R. Vasanthi, 2009. “Anti-hepatocarcinogenic Ayurvedic herbal remedy reduces the extent of diethylnitrosamine-induced oxidative stress in rats”, Pharmacognosy Magazine Vol.4, Issue 17, 19-26. (I.F. – 1.525).
  2. Vidyalakshmi K.S, Nagarajan S, Hannah R.Vasanthi, Venkappaya, and      G.V.Rajamanickam “Hepatoprotective and Antioxidant Activity of two iridoids from Mussaenda dona aurora” Z.Naturforsch C 2009 May –Jun; 64 (5-6): 329-334. (I.F. - 0.744).
  3. K.S.Jayachandran, Hannah R. Vasanthi, G.V.Rajamanickam 2009. Anti lipoperoxidative and membrane stabilising effect of diosgenin, in experimentally induced myocardial infarction” in Journal of Molecular & Cellular Biochemistry Mol Cell Biochem. 2009 327:203- 210.(I.F.-  2.329).
  4. Hannah R. Vasanthi, Subhendu Mukherjee, Istvan Lekli, Diptarka Ray, Gayathri Veeraraghavan, Dipak. K. Das, 2009. “Potential Role of Borreria  hispida in Ameliorating the Cardiovasular Risk Factors” in Journal of  Cardiovascular Pharmacology Jun; 53(6):499-506.(3.02). .(I.F.-  2.3).
  5. Nirmala A, S.Saroja and Hannah R.Vasanthi, “Effect of Basella rubra in diabetic rats”, Journal of Medicinal Food Plants, Ed.-1:10-15. 2009.
  6. A.Nirmala, S.Saroja, Hannah R. Vasanthi and G.Lalitha. “Hypoglycemic effect of Basella rubra in Streptozotocin – induced diabetic albino rats”. Journal of Pharmacognosy and Phytotherapy Vol: 1 (2) pp. 025-030. 2009.

2010:

  1. Subash Ananthi, Hanumantha Rao Balaji Raghavendran, Adoor Gopalan Sunil, Veeraraghavan Gayathri, Ganapathy Ramakrishnan and Hannah R. Vasanthi In vitro antioxidant and in vivo anti-inflammatory potential of crude polysaccharide from Turbinaria ornata (brown alga)”. Food and Chemical Toxicology. 2010; Vol.48.187-192. (I.F.- 3.215)
  2. M Vasanth kumar, R P Parameswari, V Vijaya Kumar, M K Sangeetha, V Gayathri, H Balaji Raghavendran, D Chamundeeswari and Hannah R Vasanthi. “Anti-ulcer role of Herbomineral Siddha Drug -Thamira Parpam on Experimentally Induced gastric mucosal damage in Rats”.  Human and Experimental Toxicology 2010; 29(3), 161-173. (I.F.- 1.453)
  3. R P Parameswari, M Vasanth kumar ,V Vijaya Kumar, G.Ramakrishnan,  M K Sangeetha, H Balaji Raghavendran, D Chamundeeswari and Hannah R Vasanthi. “Prophylactic role of a herbomineral drug -Thamira parpam against Cysteamine induced oxidative stress in liver and  duodenum”. Biol Trace Elem Res 2010; 138:212–225. (I.F.- 1.307)
  4. C.Chandronitha, S.Ananthi, G.Ramakrishnan, R.Lakshmisundaram, V.Gayathri, Hannah R.Vasanthi. “Protective Role of Tannin Rich Fraction of Camellia Sinensis in TissueArsenic Burden in Sprague Dawley Rats”. Human and Experimental Toxicology 2010; 29(9) 705–719. (I.F. - 1.453)
  5. K.S.Jayachandran, Hannah R.Vasanthi, G.V. Rajamanickam. “Flavonoid rich fraction of Dioscorea bulbifera Linn. (Yam) enhances mitochondrial enzymes and antioxidant status and thereby protects heart from isoproterenol induced myocardial infarction”. Curr Pharm Biotechnol. 2010; 11(8):887-894. (I.F.- 3.455)
  6. Vallinayagam Muthulakshmi, Veeraraghavan Gayathri, Subhash Ananthi, Raman Lakshmi Sundaram, Royapuram Parthasarathy Parameswari, Johnson Thanka and Hannah R  Vasanthi “Safety and bioactive potential of a traditional polyherbal formulation “Sirupeelai Samoola Kudineer” Journal of Pharmacy Research 2010, 3(9),2211-2214. (I.F.-1.1)
  7. Hannah R Vasanthi, Subhendu Mukherjee, Diptarka Ray, Karuppiah Shanmugasundara Pandian Jayachandran, Istvan Lekli and Dipak Kumar Das. “Protective role of air potato Dioscorea bulbifera) of yam family in myocardial ischemic reperfusion injury”. Food and Function. 2010; Vol: 1, 278- 283. (I.F.- 2.694)
  8. Subhash Ananthi, Veeraraghavan Gayathri, Chandranayagam Chandronitha, M.K.Sangeetha, Hannah R Vasanthi. “Antioxidant and anti-inflammatory property of Turbinaria ornat”a. Seaweed Research Utilisation 2010; 32(1& 2): 37-46. (I.F.- 1.5)

2011:

  1. Subramaniyam Rajalakshmi, Thomas Weyhermüller, Allen J. Freddy, Hannah R. Vasanthi and Balachandran Unni Nair. “Anomalous behavior of Pentacoordinate Copper complexes of dimethylphenanthroline and derivatives of terpyridine ligands: Studies on DNA binding, cleavage and apoptotic activity” European Journal of Medicinal Chemistry clear2011: 46: 608-617 (I.F.- 3.849)
  2. V. Gayathri, S. Ananthi, C. Chandronitha, G. Ramakrishnan, R. Lakshmi Sundaram, and Hannah R. Vasanthi.Cardioprotective Effect of Nerium oleander Flower against Isoproterenol-Induced Myocardial Oxidative Stress in Experimental Rats”. Journal of       Cardiovascular Pharmacology and Therapeutics. 2011: 16 (1) 96-104 (I.F.- 2.380)
  3. Dicky John Davis and Hannah R.Vasanthi, 2011 “Seaweed metabolite database(SWMD): A database of natural compounds from marine algae Bioinformation”  2011: 5(8):  361-364(I.F.0.87) 
  4. V.M. Manikandamathavan,  M. Kavitha,  V. Uma, R.P. Parameswari, Hannah R.    Vasanthi, Balachandran Unni NairCytotoxic copper (II) complex of tripyridoquinoxaline with DNA hydrolase activity”. Polyhedron  2011: 30: 1604– 1611(I.F.-1.813)
  5. Sangeetha MK, Balaji Raghavendran HR, Gayathri V, Hannah R. VasanthiTinospora cordifolia attenuates oxidative stress and distorted carbohydrate metabolism in experimentally induced type 2 diabetes in rats”. J Nat Med. 2011, 65(3-4):544-50 (I.F. - 1.516)
  6. Veeraraghavan Gayathri, Subhash Ananthi, M.K.Sangeetha, Chandranayagam Chandronitha, Hannah R Vasanthi. “Hypolipidemic potential of flowers of Nerium oleander in high fat diet fed Sprague Dawley rats”. Natural Product Research 2011. 25:11,1110-1114 (I.F.- 1.031)
  7. V Gayathri, V Muthulakshmi, C Chandronitha, M Vasanthkumar, G Ramakrishnan, S Ananthi, Sarah Kuruvilla and Hannah R VasanthiToxicological evaluation of an antilithiatic polyherbal Siddha formulation–Sirupeellai Samoola Kudineer in experimental rats”. Human and Experimental Toxicology. 2011  30:8, 952-964 (I.F. -1.42)
  8. K Gayathri, KS Jayachandran, Hannah R Vasanthi and GV Rajamanickam. “Cardioprotective effect of lemon grass as evidenced by biochemical and histopathological changes in experimentally induced cardiotoxicity”. Human and Experimental Toxicology. 2011 30: 1073-1082 (I.F. - 1.42)
  9. Verasuntharam M. Manikandamathavan, Royapuram P. Parameswari, Thomas Weyhermüller, Hannah R. Vasanthi and Balachandran Unni NairCytotoxic Copper (II) Mixed Ligand Complexes: Crystal Structure and DNA Cleavage Activity” clearEuropean Journal of Medicinal Chemistry 2011 Sep;46(9):4537-47 (I.F.- 3.849)
  10. Subhash Ananthi, Veeraraghavan Gayathri, Chandranayagam Chandronitha, Raman Lakshmisundaram, Hannah R Vasanthi. “Free radical scavenging and anti-inflammatory potential of a marine brown alga Turbinaria ornata (Tuner. J. Agardh)”. Indian Journal of Geo-Marine Sciences.October 2011 20(5):664-670. (I.F-0.563)

2012:

  1. V. Gayathri, S. Anandhi, RP.Parameshwari, Hannah R. VasanthiFree Radical Scavenging Potential and Reducing Capacity of Flowers of Nerium oleander Linn”. Journal of Herbs, Spices & Medicinal Plants. 2012 May; 18(1): 77-92 (I.F.- 0.835).
  2. Raman Lakshmi sundaram,  Ganapathy Ramakrishnan, Periyathambi Kalaivani, Veeraragavan Gayathri, Subash Ananthi, S. Saranya,  Hannah R.Vasanthi “Effectiveness of  Cassia occidentalis on pentylenetetrazole-induced Oxidative stress and kindling in rat” Asian Pacific Journal of Tropical Biomedicine 2012, 1-6. (I.F.- 0.502).
  3. Hannah R. Vasanthi, Veeresh Kumar Sali, A. Jaswanth and G.V. Rajamanickam. 2012, “Evaluation of anti gastric ulcer activities of four Gracilaria species from southeast coast of India in albino rats” Seaweed research utilisation 2012, 34 (1&2) 1-8. (I.F.- 1.5)
  4. R. Sathish R. Madhavan, Hannah R. Vasanthi Arul Amudhan " In-vitro alpha glucosidase inhibitory activity of Abraga chendooram, A Siddha drug, International Journal of Pharmacology and Clinical Sciences 09/2012; 1(3-1) 79-81.

2013:

  1. C. Chandronitha, V.Gayathri, S. Anandhi, Hannah R. Vasanthi " Restoration of arsenite induced hepato-toxicity by crude tannin rich fraction of Theobroma cacao in Sprague Dawley rats" Food Res. International 50(2013) 46-54. (I.F.- 3.378).
  2. V. Gayathri, S. Anandhi and Hannah R. Vasanthi “Antihyperlipidemic potential of polyphenol and glycoside rich Nerium Olender flower against trition WR-1339-induced hyperlipidemia in experimental Sprague Dawley rats” Journal of Chemistry, 2013 online. d.o.i 10.1155/2013/825290. (I.F.- 0.484)
  3. M.K. Sangeetha, C.D. Mohana Priya, Hannah R. VasanthiAnti-diabetic property of Tinospora cordifolia and its active compound is mediated through the expression of Glut-4 in L6 myotubes” Phytomedicine, 2013, 20, 246-248. (I.F.- 3.258).
  4. M.K.Sangeetha, D.Eazhisai Vallabi, Veeresh Kumar Sali,  J.Thanka, Hannah R. Vasanthi "Sub-acute Toxicity profile of a modified resveratrol supplement" Food and Chemical Toxicology 2013, 59, 492-500 (I.F.- 3.215).
  5. M.K.Sangeetha, Nitin Shri Shri Mal, Atmaja K., Veeresh Kumar Sali, Hannah R Vasanthi "PPAR's and Diosgenin a Chemico Biological Insight in NIDDM" Chemico biological Interactions (In press) (I.F-2.96)

2014:

  1. Somak Das, Goran Mitrovsky, Hannah R. Vasanthi and Dipak K Das, Anti-Aging Properties of a Grape-derived antioxidant are regulated by  mitochondrial balance of fusion and fission leading to mitophagy triggered by a signaling network of Sirt1-Sirt3-Foxo3-Parkin-Pink1' Oxidative Medicine and Cellular Longevity Volume 2014 (2014), Article ID 345105, 13 pages http//ds.doi.org/10.1155/2014 345105 (I.F-3.3)

Review Articles
2009

  1. Hannah R. Vasanthi, Subhendhu Mukeerjee, Dipak K. Das 2009 “Health Benefits of Broccoli: A Chemico-Biological Overview” in Mini Reviews in Medicinal Chemistry June 2009 Vol. 9. (6) 749 – 759. (I.F-2.622)
  2. Sangeetha M.K. and Hannah R. Vasanthi “Plant kingdom claims for insulin”, Sri Ramachandra University Journal of Medicine, August, 24 – 31 2009

2010

  1. Hannah R. Vasanthi and R.P.Parameswari. “Indian Spices for Healthy Heart – An Overview”.     
    Current Cardiology Reviews 2010; 6(4): 274 - 279. (I.F.-2.7)

2012

  1. Hannah R Vasanthi, R P Parameswari, Joel deLeiris and Dipak K. Das.“ Health Benefits of Wine and Alcohol: From Neuroprotection to Heart Health”. Frontiers in Bioscience (Elite Ed). 2012 Jan 1; 4:1505-12. (I.F.- 3.52).
  2. Hannah R. Vasanthi, RP Parameshwari, Dipak K. Das Multifaceted role of tocotrienols in cardioprotection supports their structure: function relation”. Genes & Nutrition. 2012 Jan; 7(1):19-28 (I.F.-3.332).
  3. Hannah R. Vasanthi, Nitin Shri Shri Mal, Dipak K.Das “Phytochemicals from Plants as Cardioprotective Agents”. Current Medicinal Chemistry 2012,May:2242-2251(I.F.-4.07).

2014

  1. Narasimhan Malathi, Sabesan Mythili, Hannah R. Vasanthi  “Salivary Diagnostics: A Brief Review” ISRN Dentistry, 2014, Volume 2014, 8 pages

Book Chapters

  1. Muthulakshmi, Vijayakumar, Vasanthkumar, Hannah R. Vasanthi “Food is Medicine and Medicine is Food – A Siddha Perspective”. Functional Food for Chronic Diseases, Ed.Danik M. Martirosyan USA - 2009 Vol.4: 274- 317.
  2. Samarjit Das, Hannah R. Vasanthi and Dipak K. Das: “Function and Biochemistry of Resveratrol” in the book Plant Phenolics and Human Health: Biochemistry, Nutrition, and Pharmacology”, Edited by Cesar G. Fraga.; Copyright 2009 John Wiley     & Sons, Inc. pp: 299:331.
  3. Hannah R. Vasanthi, Nesrin Kartal-Özer, Angelo Azzi and Dipak K.Das “Dietary  Supplements, Cholesterol and Cardiovascular Disorders in the book Modern Dietary fat Intakes in Disease Promotion” Edited by Ronald Ross Watson, Fablein De Meester and Sharma Zibadi copyright 2010 Springer Link – pp – 227 -247.   
  4. Hannah R. Vasanthi and G.V.Rajamanickam in the book Marine Pharmacology, Edited  by S. Ravikumar & K. Kathiresan; Copyright  2010  Alagappa University Publications             pp:198-210
  5. Hannah R. Vasanthi and G.V.Rajamanickam, “Marine Algae as Biomonitors  of     Pollution at Tuticorin Coast-Southeast Coast of India” in the book Coastal Hazards; Eds O.P. Varma, GV Rajamanickam & Eugene Wilson, IGC Publication pp: 94-98.
  6. Hannah R.Vasanthi “Herbal Remedies as modulators of Redox Biology in Metabolic Disorders” in the Conference Compilation Book on Oxidative Stress in Health and Disease NCOSH 2011 Edited by Narendrakannan. ISBN: 93-80697-53-6, Excel India Publishers, 2011. pp: 30-47.
  7. G. Dicky John Davis, Veeresh Kumar Sali, and Hannah R. Vasanthi,Clues for Cancer from Ocean-Derived Molecules and Role of In Silico Techniques in Anticancer Drug Discovery” in the book Marine Pharmacognosy: Trends and Applications edited by Se-Kwon Kim., December 11, 2012 by CRC Press Taylor & Francis group, 456 Pages pp393-407. ISBN 9781439892299.
  8. Dipak K. Das and Hannah R. Vasanthi, “Myocardial Adaptation and Autophagy” chapter 22 in the book Cardiac Adaptations edited by B. Ostadal and N. S. Dhalla, Springer Science+Business Media New York 2013 pp 415-432. ISBN: 978-1-4614-5202-7.

 

Honours / Awards (if any): 
  • Awarded Raman INDO-US Postdoctoral Fellowship by University Grants Commission, Govt. of India (2014-2015).
  • Recipient of AGASTHIYAR Award (2013) from Indian Association of Biomedical Scientists
  • Recipient of the Tamil Nadu Young Women Scientist Award (2009-10) in the field of Medical Sciences and Native Medicine.
  • Awarded Fellow Title of the Indian Association of Biomedical Scientists (FABMS). (2009)
  • Awarded BOYSCAST Fellowship by Dept of Science & Technology, Govt. of India (2007-2008).      
  • University of Madras XII Rank Holder in M.Sc (1994)
  • University of Madras IX Rank Holder in B.Sc (1992)
Projects Undertaken: 

ONGOING PROJECTS FUNDED BY GOVT. OF INDIA.

S.No Designation Project Title Duration Sponsoring Agency& Amount
1 Principal Investigator A pragmatic scientific evaluation of two phyto-medicines for the management of metabolic syndrome related obesity 2011-2014 DST (SERC)- Health Sciences
Rs. 44.22 Lakhs
2 Principal Investigator Anticancer Potential of Selected Marine Algae of Gulf of Mannar (South east coast of India) 2011-2014 UGC (MRP)
11.6 Lakhs
9.9 Lakhs

RESEARCH INTEREST

Drug Discovery from Natural Products

Screening of various plants both terrestrial (medicinal &ornamental) and marine (seaweeds & seagrasses) for different pathological conditions such as inflammation, cancer, diabetes, ulcers and dyslipidemia, leading to isolation of lead bioactive molecules followed by studying the mode of its action using biochemical and molecular techniques in drug discovery and development.

Standardisation and Scientific Validation of Indian System of Medicine Drugs 

Bringing our ancient traditional knowledge to the global limelight by validation of drugs of ISM is highly warranted. Based on a multidisciplinary approach some Ayurveda/Siddha drugs of herbal and herbomineral origin are being scientifically evaluated, validated and documented for diseases such as diabetes, arthritis and ulcers.    

PROFESSIONAL ACCOMPLISHMENTS

  • Publications - 60 papers
  • Presentation in conferences and seminars- 45
  • Invited Talks - 35
  • Ph. D guide for research scholars (Awarded -7, Submitted-2, Ongoing- 5 ).
  • Life Member of reputed Professional Bodies

            Association of Clinical Biochemists of India (ACBI)
            Indian Science Congress Association (ISCA)
            Indian Association of Biomedical Scientists (IABMS)
            Biotechnology Research Society of India (BRSI)
            Society for Free Radical Research (India) (SFRR)
            Seaweed Research & Utilisation Association (SRUA)
            Indian Society of Atherosclerosis Research (ISAR)
            Indian Society of Toxicology (IST)

  • Reviewer of  peer reviewed National and International Journals
  • Editorial Member in SRUA Journal
Contact Details
Present Address: 
Associate Professor, Dept. of Biotechnology, School of Life Sciences, Pondicherry University
Telephone No: 
+91 413 2654745
Mobile No: 
+91 9443135842
Email: 
hannah.dbt@pondiuni.edu.in / hrvasanthi@gmail.com
Fax No: 
+91 413 2656742