SUBBULAKSHMI.C Assistant Professor

Profile Picture

  • Department of Biochemistry & Molecular Biology
  • School of Life Sciences
  • csubbulakshmi@gmail.com

Academic Activity

Academic Activity Picture1

Academic Activity Picture2

Educational Qualification (UG,PG & Higher Order)

S.No Degree Subject/Title of thesis University/Board Year of Passing
1 Ph.D, Biochemistry University of Goettingen, Germany 2005
2 M.Sc., Integrated Biology Madurai Kamaraj University 2000
3 B.Sc., Biochemistry University of Madras 1998

Area of Specializaion

Neurodegenerative diseases of retina; Sensorineural engineering; Vesicular trafficking

Awards / Prizes Conferred

S.No Name / Title of the Award Type Name of the Agency conferred the Award Year of the Award Amount for Cash Award
1 Travel Grant NATIONAL International Congress on Cell Biology (ICCB) 2018, Asia Pacific 2017 Rs.5000
2 JNCASR Visiting Fellowship NATIONAL Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 2017 Rs.75000
3 UGC-Assistant Professorship NATIONAL University Grants Commission- Faculty Recharge Programme (UGC-FRP faculty), India 2015 Monthly Salary
4 Max Planck – India mobility fellowship INTERNATIONAL Max Planck Society, Germany and DST, India 2014 Euro12000+Rs.30000
5 International Travel grant NATIONAL Department of Science and Technology, India 2014 Rs.130000
6 Best Poster award NATIONAL Asia ARVO conference, India 2013 Appreciation letter
7 Travel Grant NATIONAL Association for Research in Vision and Ophthalmology (ARVO), USA 2013 Rs.25000
8 Best Poster award NATIONAL Society for Biological Chemists of (India) 2012 Appreciation letter
9 Japanese Society for Promotion of Science (JSPS) post-doctoral fellowship INTERNATIONAL Japanese Society for Promotion of Science (JSPS), Japan 2009 YEN 300000
10 Federation of the Societies of Biochemistry and Molecular Biology (FEBS) youth travel fund fellowship INTERNATIONAL Federation of the Societies of Biochemistry and Molecular Biology (FEBS), UK 2004 EURO 1000
11 Deutsche Forschungs Geminschaft (DFG) Graduiertenkolleg 521, Ph.D fellowship INTERNATIONAL German Research Council, Germany 2002 EURO 39600
12 Summer Research Fellowship NATIONAL Indian Academy of Sciences, Bangalore 2001 Rs.18000
13 Junior Research Fellowship NATIONAL Indian Council of Medical Research (ICMR/JRF), India 2001 not availed
14 Summer Research Fellow NATIONAL National Institute for Mental Health and Neurosciences (NIMHANS), Bangalore, India 1999 none

Teaching Experience

S.No Designation Department/Centre Institution
1 Senior Scientist Biochemistry and Cell biology Vision Research Foundation, Sankara Nethralya Eye Hospital, Chennai, India
2 UGC-Assistant Professor Biochemistry and Molecular biology Pondicherry University

Research Experience

S.No Designation Department/Centre Institution Area of Research
1 Indian Academy of Sciences Summer Research fellow Dept. of Microbiology and Cell biology Indian Institute of Science (IISc), Bangalore, India tRNA base modifications
2 Post-doctoral Fellow Dept. of Biochemistry III University of Bielefeld, Germany Exocytosis
3 Post-doctoral Researcher Dept. of Medicine Harvard Medical School, Massachusetts General Hospital, Boston, USA Endocytosis and Exocytosis
4 Post-doctoral Researcher Dept. of Medicine University of Toronto, Canada Exocytosis
5 Japanese Society for Promotion of Science Postdoc Cellular and Molecular Biophysics University of Hokkaido, Japan Exocytosis
6 Max Planck Visiting Scientist Dept. of Neurobiology Max Planck Institute for Biophysical Chemistry, Goettingen, Germany Exocytosis

Industry Experience

S.No Designation Company/Corporate Nature of Work

Patent Details

S.No Title Status Patent Number Year of Award Type Commercialized Status

Papers Published in UGC Approved Journals

S.No Title Name of the Authors as per the order in Paper Journal Name Volume, Issue & Page Nos. Year Impact Factor

Papers Published in Peer Reviewed Journals

S.No Title Name of the Authors as per the order in Paper Journal Name Volume, Issue & Page Nos. Year Impact Factor
1 Anti-angiogenic effect of adiponectin in human primary microvascular and macrovascular endothelial cells. PalanisamyK, Nareshkumar RN, Sivagurunathan S, Raman R, Sulochana KNS and Subbulakshmi Chidambaram* Microvascular Research DOI: 10.1016/j.mvr.2018.08.002 2018 2.5
2 PIWI-like protein, HIWI2:A novel player in proliferative diabetic retinopathy. Sivagurunathan S, Raman R and Subbulakshmi Chidambaram* Experimental Eye Research, 177:191-196. DOI:10.1016/j.exer.2018.08.018 2018 3.15
3 Understanding variable disease severity in X-linked retinoschisis: Does RS1 secretory mechanism determine disease severity? Sudha D, Neriyanuri S, Sachidanandam R, Natarajan SN, Gandra M, Tharigopala A, Subbulakshmi Chidambaram and Arunachalam JP Plos One 13 (5), DOI: e0198086 2018 2.8
4 PIWI-like protein, HIWI2 is aberrantly expressed in retinoblastoma cells and affects cell-cycle potentially through OTX2. Sivagurunathan S, Arunachalam JP and Subbulakshmi Chidambaram* Cellular & Molecular Biology Letters, 22:17 2017 1.3
5 Proteomic profiling of human intraschisis cavity fluid. Sudha D, Kohansal-Nodehi M, Kovuri P, Manda SS, Neriyanuri S, Gopal L, Bhende P, Subbulakshmi Chidambaram*and Arunachalam JP* Clinical Proteomics 14:13 2017 3.52
6 HIWI2 regulates tight junction proteins in retinal pigment epithelial cells through modulation of AKT/GSK3 signaling pathway. Sivagurunathan S, Palanisamy K, Arunachalam JP and Subbulakshmi Chidambaram* Molecular and Cellular Biochemistry 427(1-2):145-156 2017 2.56
7 Clinical and Genetic analysis of Indian patients with NDP-related Retinopathies. Sudha D, Ganapathy A, Mohan P, Mannan AU, Subbulakshmi Chidambaram and Arunachalam JP Int Ophthalmol doi:10.1007/s10792-017-0589-0 2017 1.34
8 Genetic studies in a patient with X-Linked Retinoschisis coexisting with Developmental Delay and Sensorineural Hearing Loss. Sudha D, Irene R, Aparna G, Smitha A, Shuba K, Srividya N, Sripriya S, Praveen S, Subbulakshmi Chidambaram and Arunachalam JP Ophthalmic Genetics 38(3) 2016 1.6
9 Peptides derived from the copper-binding region of lysyl oxidase exhibit antiangiogeneic properties by inhibiting enzyme activity: an in vitro study. Mohankumar A, Renganathan B, Karunakaran C, Subbulakshmi Chidambaram and Sulochana KN. Journal of Peptide Science doi:10.1002/psc.2675 2014 2
10 Importance of the N-terminal domain of the Qb-SNARE Vti1p for different membrane transport steps in the yeast endosomal system. Michael Gossing, Subbulakshmi Chidambaram and Gabriele Fischer von Mollard Plos One 8(6):e66304. doi: 10.1371/journal.pone.0066304 2013 2.8
11 RalA GTPase tethers insulin granules to L- and R-type calcium channels through binding α2 δ-1 subunit. Xie L, Kang Y, Liang T, Dolai S, Xie H, Parsaud L, Lopez JA, He Y, Subbulakshmi Chidambaram , Lam PP, James DE, Sugita S, Hebert Y Gaisano Traffic 14(4):428-39. doi: 10.1111/tra.12047 2013 4.1
12 Effects of ethanol metabolites on exocytosis of pancreatic acinar cells in rats. Subhankar Dolai, Tao Liang, Patrick P.L. Lam, Nester A Fernandez, Subbulakshmi Chidambaram and Hebert Y Gaisano Gastroenterology doi:10.1053/j.gastro.2012.06.011 2012 20.8
13 Dissecting Ent3p: The ENTH domain binds different SNAREs via distinct amino acid residues while the C-terminus is sufficient for retrograde transport Jana Zimmerman, Subbulakshmi Chidambaram and Gabriele Fischer von Mollard Biochem. J. 431(1):123-34 2010 3.85
14 ENTH domain proteins are cargo adaptors for multiple SNARE proteins at the TGN/endosome. Subbulakshmi Chidambaram, Jana Zimmerman and Gabriele Fischer von Mollard J Cell Sci. 1; 121(Pt 3):329-38. 2008 5
15 Specific interaction between SNAREs and epsin N-terminal homology (ENTH) domains of epsin-related proteins in trans-Golgi network to endosome transpor Subbulakshmi Chidambaram, Nina Müllers, Katrin Wiederhold, Volker Haucke, and Gabriele Fischer von Mollard J Biol Chem. 6; 279(6): 4175-9. 2004 4.3
16 Use1p is a yeast SNARE protein required for the traffic from the Golgi to the ER. Meik Dilcher, Beate Veith, Subbulakshmi Chidambaram, Enno Hartmann, Hans Dieter Schmitt and Gabriele Fischer von Mollard EMBO J 22:14, 3664-3674 2003 10.6
17 An unexpected absence of queuosine modification in the tRNAs of an Escherichia coli B strain. T. K. Dineshkumar, S. Thanedar, C. Subbulakshmi & U. Varshney. Microbiology 148: 3779-3787. 2002 2.27

Papers Published in Conference Proceedings

S.No Title Name of the Authors as per the order in Paper Details of Conference Publication Page Nos. Year
1 Expression of Piwi/piRNA in human ocular tissues: Role in maintaining functional integrity of retinal pigment epithelial cells and implication in prol Subbulakshmi Chidambaram, Suganya Sivagurunathan, Karthikka Palanisamy, Sulochana Natarajan, Pukhraj Rishi, Jayamuruga Pandian Arunachalam The Association for Research in Vision and Ophthalmology Conference proceedings published in Investigative Ophthalmology & Visual Science 55 (13), 2953-2 2014
2 Can Adiponectin be a Therapeutic Target for Proliferative Diabetic Retinopathy? S Chidambaram, V Srinivasan, K Palanisamy, P Rishi, R Selvi The Association for Research in Vision and Ophthalmology Conference proceedings published in Investigative Ophthalmology & Visual Science 54 (15), 1145-1 2013

Books

S.No Title of the Book Name of the Authors as per the order in Book Publisher Year ISBN No.

Chapters in Books

S.No Title of the Chapters Name of the Authors Title of the Book Publisher Year ISBN No.

Edited Books

S.No Title of the Book Name of the Authors as per the order in Book Publisher Year ISBN No.

Ongoing Projects

S.No Title of the Project Sponsored By Period Sanctioned Amount(Rs. Lakh) Year
1 A study on the differential expression of Piwi-interacting RNAs (piRNA) and altered Piwi-like protein interactions in Diabetic Retinopathy (PI) SERB-EMR 3 years 69.23 2018
2 Analyzing the pathological implications of the interactome of PIWI proteins in retinal degeneration (PI) Indian Council for Medical Research 3 years 45.33 2018
3 Micro-fluidic Platform for developing bio-artificial Retina (Co-PI) DBT-Task Force on Bioengineering 2 years 61.51 2018
4 UGC-Faculty Recharge Program Start up Grant (PI) University Grants Commission (UGC) 2 years 6 2017

Ongoing Consultancy Works

S.No Title of the Consultancy Work Sponsored By Period Sanctioned Amount(Rs. Lakh) Year

Completed Projects

S.No Title of the Project Sponsored By Period Sanctioned Amount(Rs. Lakh) Year
1 Understanding the effect of Adiponectin mediated signaling pathways on retinal degeneration using human retinal explant culture for designing efficient neuroprotective agent. (PI) Department of Biotechnology-Neurobiology Taskforce grant 3 years 43.73 2012
2 Regulation of SNARE exocytotic machinery under physiological and pathological conditions of diabetes and obesity. (PI) Department of Science and Technology-Young Scientist Scheme 3 years 22 2012
3 Role of adiponectin on the integrity of Blood Retinal Barrier during diabetic retinopathy, using an in vitro 3D cell culture model. (PI) Department of Biotechnology– Rapid Grant for Young Investigator 3 years 20 2011
4 Identification of interacting partners for Pigment epithelium derived factor (PEDF) in causing anti-angiogenesis. (Co-PI) Department of Science and Technology 3 years 25 2011
5 Characterization of a novel 88-kDa protein found in patients with Eale’s disease. (Co-I) Indian Council for Medical Research (ICMR) 3 years 22 2011

Completed Consultancy Works

S.No Title of the Consultancy Work Sponsored By Period Sanctioned Amount(Rs. Lakh) Year

Research Guidance - PG

S.No Year Degree No. of Students Awarded Department/Centre
1 2018 M.SC 1 Biochemistry and Molecular biology, Pondicherry Un
2 2018 M.SC 1 Biochemistry and Molecular biology, Pondicherry Un
3 2017 M.SC 3 Biochemistry and Molecular biology, Pondicherry Un
4 2017 M.SC 4 Biochemistry and Molecular biology, Pondicherry Un
5 2016 M.SC 2 Vision Research Foundation, Chennai
6 2016 M.SC 2 Biochemistry and Molecular biology, Pondicherry Un
7 2014 M.SC 1 Vision Research Foundation, Chennai
8 2013 M.SC 4 Vision Research Foundation, Chennai
9 2012 M.SC 1 Vision Research Foundation, Chennai
10 2010 M.SC 1 Vision Research Foundation, Chennai

Research Guidance - Ph.D

S.No Student Name Thesis Title Date Awarded
1 Karpagavalli M Analyzing the role of piRNAs in retinal pigment epithelium and retina
2 Rupa Ashoke Roy Dissecting the role of PIWI-like proteins in neurogenesis
3 Athira Ramesh Circadian regulation of retinal degeneration and the effect on intraflagellar transport
4 Suganya Sivagurunathan A study on functional implications of PIWI-like proteins and PIWI-interacting RNAs in human somatic and cancer cells
5 Praveen Kumar Rajan Characterization of novel neurotropic factors in retinal pigment epithelium
6 Karthikka. P Functional Characterization Of Adiponectin In Molecular Events Preceding The Onset Of Diabetic Retinopathy

Research Guidance - Post Doctoral

S.No Scholar Name Designation Funding Agency Fellowship Title Year of Joining Year of Completion

Invited Talks in Conference/Seminar/Workshop/Training Programme

S.No Title of the Paper Conferences/Seminar/Workshop/Training Programme Organized by Whether International / National / State / Regional / College or University Level From To Year
1 piRNA and PIWI-like proteins: Novel Regulators of Human Retinal Pathology National Conference on Innovations in Biotechnology School of Biotechnology, Madurai Kamaraj University National 14-12-2017 15-12-2017 2017
2 Exosomes: the nanovesicles in diagnostics Annual Physiologist and Pharmacologist of India Conference (APPICON 2017) JIPMER, Pondicherry National 10-10-2017 14-10-2017 2017
3 PIWI-like proteins and Somatic cells: A missing Link Young Investigator Meet 2017, Goa NCBS-India biosciences National 06-03-2017 10-03-2017 2017
4 Proteomic profiling of Intraschisis fluid from X-linked Retinoschisis (XLRS) patients Proteomics day celebration and Seminar on Clinical Proteomics Aravind Medical Research Foundation, Madurai National 18-03-2017 19-03-2017 2017
5 Novel functions of Piwi-interacting RNAs (piRNA) and PIWI proteins in somatic cells 2nd International Conference on “Structural and Functional Genomics” (ICSAFG-2016) SASTRA Unviersity, Tanjore Internatational 19-08-2016 20-08-2016 2016
6 Expression of PIWI proteins in somatic tissues and the role in retinal epithelial transport Public Seminar University of Bielefeld, Germany International 25-06-2016 25-06-2016 2016
7 PIWI interacting RNAs in retinal pathology National Workshop entitled Decoding the Non-Coding Central University of Kerala, Kerala National 18-02-2016 19-02-2016 2016
8 Impact of primary cell culture and cell based therapy in ophthalmic diseases National Seminar on ‘Application of mammalian cell culture in translational research’ Sathyabama University, Chennai National 30-10-2015 30-10-2015 2015
9 Role of adiponectin in proliferative diabetic retinopathy SERB School in Neuroscience DST, Bhubaneswar National 10-12-2012 22-12-2012 2012

Conferences/Seminars Organized

S.No Title of the Programme Sponsors Venue & Duration Whether International / National / State / Regional / College or University Level From To Year
1 Advanced Protein Detection Techniques GE and Pondicherry University Department of Biochemistry and Molecular biology, one day National 13-10-2017 13-10-2017 2017
2 National Seminar on Current Topics in Biological Research Pondicherry University Department of Biochemistry and Molecular biology, one day National 20-10-2017 20-10-2017 2017

Workshop Organized

S.No Title of the Programme Sponsors Venue & Duration Whether International / National / State / Regional / College or University Level From To Year

Affiliation in Academic Bodies/Societies

S.No Name of the Body/Society Nature of Affiliation Year
1 Association for Research in Vision and Ophthalmology, USA Annual Member 2014
2 Indian Society for Cell Biology Life Member 2012
3 Society for Biological Chemists of India Life Member 2012

Participation & Extension Activities (Academic/Administraion)

S.No Name of the Position (Head, Dean, Co-ordinator, Director, etc.,) Duration Nature of Dutites
1 Purchase Committee member, JIPMER, Pondicherry 3 years To analyze quotations and other documents for approval of the purchase
2 Purchase Committee member, Dept. of Biochemistry and Molecular biology, Pondicherry University 3 years To analyze quotations and other documents for approval of the purchase
3 Doctoral Thesis Advisory Committee member 3 years Evaluate and suggest improvements for doctoral thesis work
4 Member of Board of Studies 3 years For scrutinizing M.Sc., syllabus
5 Reviewer for Elsevier and Medknow journals 3 years To review the manuscripts

Participation & Extension Activities (Co-Curricular)

S.No Name of the Position (NSS, NCC, Warden etc.,) Duration Nature of Dutites
1 Judge for State Level Science Exhibition, Puducherry 3 days Evaluating the best exhibits for awards

Collaboration with Institution/Industry

S.No Collaborator Name Institution/Industry Nature of Collaboration Details of Collaborative Research/Teaching
1 Dr. Prajakta Dandekar Jain Institute of Chemical Technology (ICT), Mumbai Joint Research Grant Micro-fluidic Platform for developing bio-artificial Retina
2 Prof.Reinhard Jahn Max Planck Institute for Biophysical Chemistry, Göttingen, Germany Joint Research Grant Max Planck – India mobility grant

E-Lecture Details

S.No E-Lecture Title Development of e-content/e-learning/delivering Member of Editorial Bodies Reviewer/Referee of
Content/Module Title Institution/Platform Year Weblink